This annual publication is the NTS Centre’s reflections on the events of the past year and contemplations on issues of non-traditional security in Southeast Asia and beyond. In 2021, the world recovered from the COVID-19 pandemic slowly while the virus kept mutating and spreading. Meanwhile, the effects of climate change continue to intensify, posing an existential threat to mankind and requiring immediate and decisive action of all countries. The NTS Year In Review 2021 includes a series of insightful articles on COVID-19 and climate change, highlighting possible mitigation measures and future actions. It comprises articles which discuss the intersections of different NTS challenges confronting the region, such as food security, climate change, migration, and humanitarian crises. These articles draw out some of the potential pathways for addressing the complex challenges in the region. We hope that you will find these articles useful in providing a holistic understanding of the kinds of challenges we face today. Finally, as always, we showcase our Centre’s activities for the year and the varied publications of our researchers in 2021.